IGF-1 LR3 (1MG)

IGF-1 LR3 — the Long-R3 IGF-1 analog (Arg³-IGF-1 with N-terminal extension) — supplied by BioFusion as a vacuum-sealed lyophilized 1mg vial for IGF-receptor and IGFBP-binding-displacement research chemistry.

Research context

IGF-1 LR3 (Long-R3 IGF-1) is an 83-residue research analog of native IGF-1 with two structural changes: an arginine substitution at position 3 (Arg³) that disrupts IGFBP-binding, and a 13-residue N-terminal extension that further reduces IGFBP affinity. The result is a research peptide with reduced binding-protein sequestration relative to native IGF-1 — making it a frequent reference standard in IGF-receptor binding and downstream-signaling research panels.

Synthesis & documentation

Produced by solid-phase peptide synthesis using Fmoc protecting-group strategy in a U.S.-based ISO 9001:2008 facility. Each lot is verified for identity (LC-MS), purity (reverse-phase HPLC-UV ≥99.0%), moisture (Karl Fischer), and counter-ion (ion chromatography). The signed Certificate of Analysis ships with every order; lot archive on the COA library.

Storage & handling

Lyophilized IGF-1 LR3 is stable at −20 °C for the printed shelf life. After reconstitution, the standard 14-day-at-2-8 °C reference window applies; avoid freeze-thaw cycling. At 83 residues with three intramolecular disulfide bridges, IGF-1 LR3 is sensitive to reducing-agent contamination — handle accordingly. The reconstitution calculator handles concentration math.

Why BioFusion

83-residue peptides with three disulfide bridges are at the upper bound of what SPPS can deliver at ≥99% purity — many third-party “IGF-1 LR3” listings are actually mis-folded or partially-reduced batches. BioFusion’s lots are verified for correct disulfide-bridge formation and ≥99.0% reverse-phase HPLC purity. Batch transparency ledger publishes per-release data. Bulk discounts at three+; members save 25%.

For research and laboratory use only. This product is not a drug, food, or cosmetic, and is not intended for diagnostic, therapeutic, or in vivo human use.