MOTS-c (10MG)

MOTS-c — Mitochondrial Open Reading Frame of the 12S rRNA — is a 16-residue mitochondrial-derived peptide encoded within the 12S ribosomal-RNA gene of the mitochondrial genome. BioFusion supplies it as a vacuum-sealed lyophilized vial of 10mg for bioenergetics and metabolic-pathway research.

Research context

MOTS-c is one of the most-cited mitochondrial-derived peptides in 2020-2025 research literature, alongside humanin and the SHLP family. Its 16-residue sequence (MRWQEMGYIFYPRKLR) is encoded within the 12S rRNA gene rather than as a conventional protein, and the synthesized reference standard is used as the comparator in pathway-mapping, AMPK-activation, and mitochondrial-bioenergetics chemistry studies. The free MOTS-c chemistry primer walks through sequence, encoding, synthesis, and stability considerations.

Synthesis & documentation

Produced by solid-phase peptide synthesis using Fmoc protecting-group strategy in a U.S.-based ISO 9001:2008 facility, then verified for identity (LC-MS), purity (reverse-phase HPLC-UV ≥99.0%), moisture content (Karl Fischer), and counter-ion (ion chromatography). Each lot ships with its signed Certificate of Analysis. The COA library retains documentation for every released batch.

Storage & handling

Lyophilized MOTS-c is stable at −20 °C for the printed shelf life. After reconstitution with bacteriostatic water or saline, reference-stability data supports use within fourteen days at 2-8 °C protected from light. The methionine residue at the N-terminus is moderately oxidation-sensitive — minimize exposure to atmospheric oxygen and store dilutions in low-headspace vials. The reconstitution calculator handles concentration math.

Why BioFusion

Mitochondrial-derived peptides are challenging to synthesize accurately at production scale; methionine oxidation and incomplete deprotection are common failure modes. BioFusion’s MOTS-c is verified post-synthesis for identity and purity, with synthesis-date metadata published in the batch transparency ledger. Bulk discounts trigger at three+ vials; members save 25% on every order plus complimentary U.S. shipping for 365 days.

For research and laboratory use only. This product is not a drug, food, or cosmetic, and is not intended for diagnostic, therapeutic, or in vivo human use.